ANTI INFLAMMATORY ACTIVITY OF CORIANDER OLEORESIN MEDIATED SELENIUM NANOPARTICLES | PLANT CELL BIOTECHNOLOGY AND MOLECULAR BIOLOGY

The aim of this study was to assess the anti-inflammatory activity of selenium nanoparticles mediated by Coriander Oleoresin.

Materials and Methods: Coriander oleoresin-mediated Selenium nanoparticles were made by combining 0.5 mL Coriander Oleoresin extract with 0.519 g sodium selenite in 99.5 mL distilled water. For nanoparticle synthesis, the reaction mixture was held in an orbital shaker with magnetic stirrer. Color shift indicated the formation of selenium nanoparticles, which was confirmed using a UV-Visible spectrophotometer. The antiinflammatory activity of coriander oleoresin mediated selenium nanoparticles was assessed using an albumin denaturation inhibitory assay.

Discussion and Conclusions: The presence of selenium nanoparticles was demonstrated by a colour shift in the reaction mixture, which was verified by UV-Visible spectroscopy with a peak at 320nm. The anti-inflammatory activity of coriander oleoresin mediated selenium nanoparticles was dose dependent. At 50 L of selenium nanoparticles, the maximum inhibitory effect of 90 percent on protein denaturation was observed.

Conclusion: The synthesis of selenium nanoparticles in a green manner was simple and straightforward. The researchers concluded that Coriander Oleoresin-mediated Selenium nanoparticles had strong anti-inflammatory activity and thus could be used for a healthy and environmentally friendly selenium nanoparticle synthesis for inflammatory conditions.

Please see the link :- https://www.ikprress.org/index.php/PCBMB/article/view/5543

ANTIMICROBIAL ACTIVITY OF CLOVE AND CINNAMON FORMULATION MEDIATED SELENIUM NANOPARTICLES AGAINST ORAL PATHOGENS | PLANT CELL BIOTECHNOLOGY AND MOLECULAR BIOLOGY

Background: A large range of fields, including medicine in particular, have been modernised by the advent of nanoparticles (NPs). By minimising the toxicity and side effects that commercially available drugs may have on patients, nanoparticles have revolutionised targeted drug delivery. In herbal medicine, cloves and cinnamon have long been used for the treatment of a broad range of ailments and diseases. The green synthesis of nanoparticles has been gaining importance because of its simplicity and eco-friendliness.

Goal: The aim of this study was to synthesise selenium nanoparticles mediated by clove and cinnamon formulations and evaluate their antimicrobial activity against oral pathogens.

Materials and Methods: Selenium nanoparticles mediated by clove and cinnamon formulations were synthesised in vitro. The antimicrobial activity of SeNPs was tested using the Kirby Bauer disc diffusion method against Streptococcus mutans and Lactobacillus.

Results: SeNPs mediated by clove-cinnamon extract showed effective antimicrobial activity comparable to that of drugs commercially available.

Conclusion: It can thus be inferred that selenium nanoparticles mediated by clove-cinnamon have the potential to be used as an effective antibiotic. To isolate the component in the extract that makes it effective to be used in large-scale production for targeted drug delivery against a wide range of oral microbial infections, this formulation needs to be further purified.

Please see the link :- https://www.ikprress.org/index.php/PCBMB/article/view/5350