In silico ANALYSIS OF EFFECT OF PHYTOCHEMICALS FROM Paprika oleoresin (Capsicum annum L.) AGAINST DIAMINOPIMELATE DEHYDROGENASE OF Clostridium tetani CAUSING TETANUS | PLANT CELL BIOTECHNOLOGY AND MOLECULAR BIOLOGY

 Tetanus is caused by Clostridium tetani. Strikingly, during particular molecular events, tetanus increases mainly, thereby serving as a possible clinical biomarker. Furthermore, further downstream events can also be triggered by tetanus, promoting the detrimental process. Several bio molecules can be deployed to reduce the activity of tetanus, the phytochemicals of which may be the best option. Molecular docking-based screening of a few phytochemicals showed that the phytochemicals interact effectively with the protein's active site and thus have diagnostic and therapeutic tetanus potential.

Please see the link :- https://www.ikprress.org/index.php/PCBMB/article/view/5246

Moringa oleifera DERIVED PHYTOCHEMICALS AGAINST MALARIA: AN In silico ANALYSIS | PLANT CELL BIOTECHNOLOGY AND MOLECULAR BIOLOGY

 Phytochemicals are plant derived biomolecules which are believed to protect cells from damage. It has been reported that Moringa oleifera L. (Moringaceae) is n economically important plant, distributed across tropics and subtropics whose extract is used to cure malaria. The plant extract contains different phytochemicals. Malaria is caused by Protozoan Parasite Plasmodium. L-Lactate dehydrogenase is one of its vital enzymes. In silico approach using Biovia’s Discovery Studio was used to see the molecular docking between phytochemicals derived from Moringa oleifera L. and the enzyme of interest. -CDOCKER energy and –CDOCKER interaction energy represents the strength of the interaction. Particularly, the phytochemicals hexadecanoic acid and anthraquinone can effectively deactivate the L-Lactate dehydrogenase enzyme and thus can interfere with the life cycle of Plasmodium.

Please see the link :-  https://www.ikprress.org/index.php/PCBMB/article/view/5170

PEEL OF Citrus reticulata DERIVED PHYTOCHEMICALS AGAINST GLYCERALDEHYDES- 3 – PHOSPHATE OF ENTAMOEBA HISTOLYTICA | PLANT CELL BIOTECHNOLOGY AND MOLECULAR BIOLOGY

 The phytochemicals or secondary metabolites from extract of Citrus reticulata may cure dysentery, primarily which is caused by Entamoeba hystolytica. To restrict the activity of Entamoeba hystolytica, several bio molecules can be deployed, of which the phytochemicals can be the best alternative. Molecular docking-based screening of a few phytochemicals revealed that few of phytochemicals effectively associate with the active site of the Glyceraldehydes- 3 – Phosphate and hence bears diagnostic and therapeutic potentials against Entamoeba hystolytica causing dysentry. “High positive values of -CDOCKER energy and -CDOCKER interaction energy” indicated that the Anthranalic acid may effectively inhibit the glyceraldehydes-3-phosphate dehydrogenase enzyme thereby interrupting the life cycle of the organism.

Please see the link :-  https://www.ikprress.org/index.php/PCBMB/article/view/5169