Aim: The aim of the study is to investigate the antimicrobial and cytotoxic effect of Adhatoda vasica mediated copper nanoparticles.
Introduction:
Conventional medical drugs have specific targets, but typically also cause
significant side effects. Throughout Ayurveda, the conventional form of Indian
medicine is commonly referred to as vasaca, which may be a well-known herb in
the indigenous drug system. It acts as a sedative, expectorant, antispasmodic,
anthelmintic, bronchial antiseptic and bronchodilator.
Materials and
Methods: Copper nanoparticles were synthesised separately and then mixed in
equal proportion with the prepared plant extract. Centrifugation was done and
the pellets were collected separately after the process for further testing.
Microorganisms such as S. mutans, Lactobacillus and Candida albicans were
chosen and cultured in respective culture media. The Copper Nanoparticles
synthesised is introduced into cultured petri plates to observe the changes.
For calculating the cytotoxic activity, dividing the estimated number of dead
nauplii to the total number and the proportion of motility was calculated.
Results: The
zone of inhibition was found to be increasing in both bacterial and fungal
species as the concentration of A. vasica CuNP increases. Therefore, A. vasica
CuNP was shown to have more effective antimicrobial activity than the standard
antibiotics. The cytotoxic effect of A. vasica CuNP shows that as the
concentration increases there is a significant increase in the percentage of
lethality.
Please see the link :- https://www.ikprress.org/index.php/PCBMB/article/view/5331
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