ANTI INFLAMMATORY AND CYTOTOXIC EFFECT OF CLOVE AND CINNAMON HERBAL FORMULATION | PLANT CELL BIOTECHNOLOGY AND MOLECULAR BIOLOGY

Background: Inflammation, such as dental caries, gingivitis, periodontitis and oral mucosal lesions, is the main finding in oral diseases. In order to reduce inflammation, it is important to invent new topical agents. In the pharmaceutical industry, plant extracts are commonly used since they are naturally available and have less side effects.

Goal: The aim of this study is to test the anti-inflammatory and cytotoxic effects of herbal formulations of cloves and cinnamon.

Materials and Methods: Ground cloves and cinnamon. 5 grammes of clove powder and 5 grammes of cinnamon powder were weighed and mixed with 100 ml of distilled water. The clove and cinnamon aqueous extract was prepared. By using brined shrimp nauplii, the extract was then tested for cytotoxicity. Bovine Serum Albumin has been used to detect the extract's anti-inflammatory function.

Results: The aqueous clove extract and cinnamon extract displayed the highest absorption at a concentration of 50 μl (90.3%) when the albumin denaturation assay was inhibited to verify its anti-inflammatory activity at a wavelength of 660 nm. At 10 μl, the cytotoxicity of the extract was the lowest.

Conclusion: The prepared clove and cinnamon extract has proven to be a potent antioxidant and antimicrobial agent and can therefore be used in medical applications. The cytotoxicity assay showed that the extract can be integrated into biomedical applications, thereby concluding that clove and cinnamon extract can be a groundbreaking step in the transition to greener medicine.

Please see the link :- https://www.ikprress.org/index.php/PCBMB/article/view/5341