THE ROLE OF TIME TO MAXIMUM PARAMETER IN THE QUANTIFICATION OF THE ISCHEMIC PENUMBRA FOR DSC-MRI IMAGING | Journal of International Research in Medical and Pharmaceutical Sciences

 Background: To assess hypoperfused cerebral parenchyma, the period to limit of the tissue residue feature (Tmax) is a widely used parameter. The post-processing programme to measure Tmax, on the other hand, is a problem because it is optional, costly, and requires a powerful workstation.

The aim of this study was to show how to build a perfusion imaging analysis workflow that produces accurate and repeatable Tmax maps. The perfusion signal is estimated from the data given by the MRI method, which is the first step in the quantification process. After that, the curve is transformed into a focus curve. The Arterial Input Function (AIF) is then determined using an automated process, followed by deconvolution using the Singular Value Decomposition (SVD). Finally, we measured the parameter Tmax and used thresholds to produce the mapping of this parameter.

Healthy volunteers, patients with reported brain infarction, and two patients with no mismatch were used to assess the clinical utility. The Tmax parameter's output was also compared to that of the standard semi-quantitative analysis (time-to-peak (TTP) parameter).

Conclusion: The Tmax map provides a fast and reliable estimate of the hypoperfused cerebral parenchyma, according to the findings. The TTP parameter results in a much better solution with smoother edges and more detailed details.

Please see the link :- https://www.ikprress.org/index.php/JIRMEPS/article/view/5623