Background: Sorbitol, also known as glucitol, is a sweet-tasting sugar alcohol that metabolises slowly in the human body. The polyol pathway, also known as the sorbitol-aldose reductase pathway, appears to be involved in diabetic complications, particularly microvascular damage to the retina, kidneys, and nerves. (Botanical name: Punica granatum; family: Punicaceae). Pomegranate juice reduces lipid peroxidation in type 2 diabetics and hypertensive patients, as well as systolic blood pressure and serum angiotensin converting enzyme activity.
The aim of this study was to see how effective pomegranate extract is at
preventing sorbitol accumulation (Punica granatum).
Plant materials-Punica
granatum extract was obtained from Green Chem Herbal extracts and formulations,
Bengaluru, India, for use in the research.
The technique
used to extract the above plant material was developed by Kesavanarayanan et
al. in 2013.
Results:
Punica granatum extract inhibited sorbitol formation significantly, with an
IC50 of 48.51g/mL compared to 37.77g/mL for regular ascorbic acid.
Please see the link :- https://www.ikprress.org/index.php/PCBMB/article/view/5620
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