The present study was
designed to evaluate the antibacterial activities of Swietenia macrophylla
crude methanolic (SMCM) seed extract. The antimicrobial activity of the oily
extract against Gram-positive, Gram-negative, yeast and fungus strains was
evaluated based on the inhibition zone using disc diffusion assay, minimal
inhibition concentration (MIC) and minimal bactericidal concentration (MBC)
values. The crude extract was subjected to various phytochemicals analysis. The
demonstrated qualitative phytochemical tests exhibited the presences of common
phytocompounds including alkaloids, terpenoids, antraquinones, cardiac
glycosides, saponins, and volatile oils as major active constituents. The SMCM
seed extract had inhibitory effects on the growth of Candida albicans, Bacillus
subtilis, Escherichia coli, Pseudomonas aeruginosa and illustrated MIC and MBC
values ranging from 25 mg/ml to 50 mg/ml.
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