The aim of this research is to make zinc oxide nanoparticles from Punica granatum and Elettaria cardamomum, measure their antifungal activity against Candida albicans, and see how toxic they are.
Introduction: Zinc oxide nanoparticles are commonly used in medicine and
science due to their inherent antimicrobial, antioxidant, and anti-inflammatory
properties, as well as their low toxicity. The green synthesis of these
nanoparticles is favoured because it is simple, relatively repeatable,
cost-effective, and produces more stable, non-toxic materials.
Materials and Methods: Green zinc oxide nanoparticles were made from aqueous
fruit extracts of P. granatum and E. cardamomum. UV spectroscopy and scanning
electron microscopy were then used to determine the properties of
nanoparticles. The agar well diffusion method was used to assess antifungal
activity, and the brine shrimp lethality assay was used to assess cytotoxicity.
P. granatum and E. cardamomum extracts allowed the synthesis of stable zinc
oxide nanoparticles, according to the findings. The nanoparticles thus produced
were also found to have strong antifungal properties, with a zone of inhibition
of 12mm for 50L, 22mm for 100L, and 24mm for 150L. In a lethality assay, 80
percent of live shrimp larvae were found in a nanoparticle concentration of
20-30 L. The cytotoxicity of the nanoparticles, on the other hand, needs to be
investigated further. They may be integrated into various products in the
future, such as toothpaste, mouthwash, and mouth paint, to promote their
effect.
Please see the link:- https://www.ikprress.org/index.php/PCBMB/article/view/5582
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