ANTIFUNGAL ACTIVITY OF Acacia catechu SEED EXTRACT- AN in vitro STUDY | PLANT CELL BIOTECHNOLOGY AND MOLECULAR BIOLOGY

An antifungal is an agent that destroys or inhibits the production of microorganisms including Candida albicans, Aspergillus niger, etc. Acacia catechu is a deciduous, thorny tree that grows up to 15 m (50 ft) in height, often commonly referred to as Mimosa catechu. Traditionally, Acacia catechu is used for treating many diseases and is widely used for healthcare for mothers and infants. Taxifolin, which has antiviral, antibacterial, anti-inflammatory and antioxidant function, is the key constituent of Acacia catechu. The fungal cultures were swabbed on sterile plates which contained Sabouraud dextrose agar. Wells with a diameter of 6 mm were bored into each plate. The wells were packed with differing sample concentrations. For assessment, the plates were incubated at 28 ° C for 72 h. In millimeters, the diameter of inhibition zones formed around the wells was measured. For all the samples, the analysis was carried out in duplicates. The study shows that acacia catechu seed extract is highly successful in demonstrating antifungal activity against the fungal pathogens Aspergillus niger and Candida albicans (a concentration of 2.0 mg/ml showed an inhibition zone of 13.5 mm for Candida albicans and an inhibition zone of 7.5 mm for Aspergillus niger on average). The higher the extract's concentration, the greater the antifungal activity. The above study shows that acacia catechu seeds have a high degree of antifungal activity against pathogens causing diseases and can be used to remove the oral manifestations caused by these species in dentistry.

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