FORMULATING A VITAMIN D DELIVERY TOOTHPASTE USING A PENETRATION PROMOTOR | Journal of International Research in Medical and Pharmaceutical Sciences

The functions of toothpaste have recently been diversified from the mere functions of removing dietary waste, inhibiting bacterial development, and improving the colour of whiter teeth. In order to extend toothpaste uses, many toothpastes prefer to include attractive scents, colours, and active ingredients. Vitamin D is particularly important because it facilitates the absorption of calcium in the intestine, enhances the development of the bone and reshapes osteoblasts and osteoclasts. In 42 percent of the American population today, widespread vitamin D deficiency has been found.

Vitamin D is a fat-soluble vitamin which is naturally present, added to others and available as a dietary supplement in very few foods. Thus, the value of vitamin D dietary supplements should not be ignored. However, taking pills regularly is almost difficult.

Objective: The purpose of the study was to promote successful daily dosing of vitamin D on a long-term basis via intraoral administration during toothbrushing.

Methods: With distilled water, olive oil, and emulsifying wax, an emulsion-based toothpaste was developed. And other typical ingredients were then homogeneously combined with azone and vitamin D3, a potent penetration promoter. After formulating the vitamin D toothpaste, the various characteristics of our vitamin D3 toothpaste, such as abrasiveness, scratchiness, spreadability, pH, foaming and cleaning ability, were compared with those of other commercial toothpaste brands. A transepithelial electrical resistance (TEER) measurement was performed using Lumbricus terrestris skin to ensure the intended delivery of vitamin D3 via the oral cavity.

Conclusions: The general characteristics of our vitamin D toothpaste did not vary substantially from commercial brand toothpastes. The feasibility of vitamin D3 delivery was demonstrated on the basis of the increase in TEER values for the vitamin D toothpaste community, although the invertebrate model may have some limitations. With more enhanced transport research, further studies should be carried out. Some new insight into the drug delivery application of toothpaste should be given by the intraoral delivery analysis for vitamin D.

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