EFFICACY OF Azadirachta indica ESSENTIAL OIL BIO-COMPOUNDS AGAINST csuE AMONG Acinetobacter baumannii - AN in-silico ANALYSIS | PLANT CELL BIOTECHNOLOGY AND MOLECULAR BIOLOGY

Introduction: Acinetobacter baumannii has become one of the most prominent pathogens which, particularly in intensive care units, cause a wide range of serious infections. CsuE-mediated biofilm formation plays a role in biotic and abiotic substrates being bacterially attached. In vivo, biofilms are heterogeneous, containing numerous microorganisms that associate with each other and form a complicated population of multiple species. Azadirachta indica (neem) is a world-renowned medicinal plant that has, since time immemorial, a long history of use in various diseases in traditional Indian medical systems (Ayurveda, Unani, Tibetan).

Content and Methods: Compound effectiveness in A. Using bioinformatics databases and resources such as ramachandran validation and auto-docking method, Indica essential oil against csuE was evaluated.

Results: The drug and the ligands were found to be promising in structure retrieval. The selected bioactive compounds of A were shown by drug-ligand interactions. Indica and Ceftazidime control drugs were successful against the development of A by csuE. From baumannii. Imidazole-2-carboxylic acid, 4-methyl, and ethyl 6,8-difluro-4-hydroxyquinoline-3-carboxylate have been found to have heavy hydrogen bonds and fewer binding energies in csuE.

Conclusion: We have found a promising interaction between bioactive compounds of A within the constraints of this analysis. Ndica and A. csuE genes. Baumannianiii

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