Background:
Zinc oxide nanoparticles are a type of metal oxide nanoparticles with a band
gap of 3.3 eV and excitation binding energy of 60 meV at room temperature. It
has gained considerable attention due to its unique catalytic, antibacterial,
antifungal, photochemical, UV-filtering, anti-inflammatory properties owing to
its large surface area to volume ratio. Synthesis of metal and metal oxide
nanoparticles through green routes and environmentally benign methods has been
focused by researchers to avoid the use of toxic chemicals making the process
and the final product eco-friendly and non-toxic in nature.
Aim: To assess the cytotoxic effect of grape seed mediated zinc oxide
nanoparticles using brine shrimp lethality assay.
Materials and Methods: Plant extracts were collected and prepared for obtaining
the grape seed extract. Zinc oxide nanoparticles were then synthesised in a
methodological manner, followed by the assessment and characterisation of the
zinc oxide nanoparticles. The zinc oxide nanoparticles powder was then
prepared. Brine shrimp lethality assay was the test used to identify the
cytotoxic activity of the grape seed mediated zinc oxide nanoparticles and the
results were statistically analysed.
Results:
Cytotoxic activity of zinc oxide nanoparticles was verified through several
tests such as Brine shrimp assay. It was observed that the initial number of
nauplius reduced in a negligible amount after one day and very little after
three days in only certain concentrations of Zinc oxide nanoparticles.
Please see the link :- https://www.ikprress.org/index.php/PCBMB/article/view/5360
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