Background: In today’s age, the incidence of local and systemic fungal diseases has increased due to a rise of new and fatal immunodeficiency diseases as well as immune-suppressive therapy due to which there is a heightened increase in the use of antifungal drugs which have significant side effects. Nanotechnology is rapidly growing in various fields of science.
Aim: To
determine the antifungal activity of grape seed-mediated titanium dioxide
nanoparticles against Candida albicans.
Materials and
Methods: The collected grape seeds were powdered and stored in an airtight
container. 1 g of grape seed extract was mixed with 100 ml of distilled water
and was boiled for 15 minutes. The solution was filtered, to which 20 ml of
distilled water was added. To this solution 0.862 g of titanium dioxide was
added and was subjected to constant stirring until the formation of white
suspension. This was centrifuged for 10 minutes and the antifungal property
against Candida albicans was assessed.
Results: The
peak found at 650 nm in the UV spectroscopy indicates the formation of titanium
dioxide nanoparticles. From the study it was found that with the increase in
the concentration of the grape seed mediated titanium dioxide nanoparticles,
the zone of inhibition against C. albicans was increased. The highest zone of
inhibition obtained was 12 mm at 150 microliters.
Please see the link :- https://www.ikprress.org/index.php/PCBMB/article/view/5379
No comments:
Post a Comment