HIV Infection and Therapeutic Interventions: Review on HIV Infection Biology, Highly Active Antiretroviral Therapy (HAARTs), Hepatotoxicity, Nephrotoxicity and Dyslipidemia

Abstracts

Three and half decades following the identification of HIV, the disease remains a global health concern as people get infected with the virus which has no cure coupled with the unavailability of vaccines. The discovery of some drugs has classified the disease into a chronic disease category. These drugs have dramatically reduced the high morbidity and mortality associated with HIV/AIDS. However, the disease has become a double-edged saw as both sides have their negative implications thus, the virus suppressing the immune system and the drugs which are intended for treatment induce toxicities in some major organs. This paper summarized the biology behind HIV infection, the therapeutic intervention and the effects of the therapeutic intervention on the liver, kidney and lipid metabolism.

Keywords : Hepatotoxicity; nephrotoxicity; dyslipidemia; HAART; HIV infection; CD4.

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