ANTI-BIOFILM EFFICACY OF O. sanctum ESSENTIAL OIL COMPOUNDS AGAINST KPSMT GENE OF A. baumannii - AN in-silico APPROACH | PLANT CELL BIOTECHNOLOGY AND MOLECULAR BIOLOGY

Introduction: Strains of Acinetobacter are thought to be past nosocomial pathogens. O's anti-biofilm effect. Using bioinformatics software and databases, Sanctum essential oil compounds against Kpsmt were evaluated.

Materials and Methods: Kpsmt gene in-silico docking and selected O. ligand structures. Critical sanctum oils have been carried out. Results of Molinspiration were carried out to determine the drug-like properties of the bio-compounds selected. To test the drug-ligand interactions, the final auto dock was performed and evaluated based on the number of hydrogen bonds and the binding energies of the ligands selected.

Results: The study result refers to benzofurans as the promising drug from O. For targeting the Kpsmt gene, sanctum essential oils. When compared with the control drug ceftazidime, benzofuran was found to have higher hydrogen bonds and lower binding energy.

Conclusion: Computational molecular docking may be used for the drug development process as an important supporting method. Further experimental validation for novel drug design and discovery in the near future is needed, however.

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