In the treatment of cardiovascular disorders, calcium channel blockers (CCB) are used for their action on voltage sensitive calcium channels in the cardiac and smooth muscles. In regulating the release of neurotransmitters from the peripheral and central terminals, N-type calcium channels are of particular importance. Nifedipine is a potent agent used in cardiovascular diseases such as hypertension and angina, and is a treatment that most patients take chronically. The purpose of this study is to examine the effects of nifedipine on anxiety, actions, memory, motion, and other parameters of the CNS in order to provide information on side effects and drug repurposing. For this analysis, three separate sets were used for twenty-five mice each. Twenty five mice were randomly divided into five classes (n = 5) for the neurobehavioral models (open area, hole floor, elevated plus maze, Y maze, and activity cage). Two controls (distilled H2O and diazepam) and three treatment groups for doses of 0.15, 0.30 and 0.6 mg/Kg/Kg are included in these groups (calculated based therapeutic dose of nifedipine). According to the community above the muscle relaxant models (traction test and inclined plane) were performed using another set of twenty five. According to the five classes mentioned above the third set of twenty-five animals were also used for the pentobarbitone induced hypnosis examination. The findings of this study indicate that nifedipine does not have a CNS depressant effect, although chronic administration of 0.15 mg/kg has shown otherwise. At a chronic dose of <0.3 mg/kg, nifedipine exhibits an anxiogenic effect. Central depressive activity can be seen when a high dose of Nifedipine is administered. Chronic use of Nifedipine has a mild learning and memory effect.
Please see the link :- https://www.ikprress.org/index.php/JIRMEPS/article/view/5265
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