Background: Antibiotic resistance is a rising problem that needs attention which is of global concern. The main reason behind the prevalence of such situations is the haphazard use of the antimicrobial drugs that are overused throughout therapeutic treatment of infection. Additionally, the issues associated with modern- day chemotherapeutics can have a wide range of adverse effects from allergy to immunosuppression.
Aim: To
assess the antimicrobial and antioxidant activity of clove and cinnamon herbal
formulation.
Materials and
Methods: Clove and cinnamon were dried and powdered, the powdered clove and
cinnamon were then mixed with water and ethanol. The aqua alcoholic extract
thus obtained was then subjected to DPPH assay to analyze its antioxidant
effect and was loaded in the agar wells made on Muller Hinton agar so as to
assess its antimicrobial activity by using well diffusion method, against
Streptococcus mutans, Lactobacillus and Streptococcus aureus and the zone of
inhibition was noted.
Results: The
aqua alcoholic extract of clove and cinnamon extract showed highest absorbance
at a concentration of 50 μl (132.3%) when subjected to inhibition of albumin
denaturation assay to check for its antimicrobial activity at a wavelength of
660 nm. The zone of inhibition for the prepared extract against Streptococcus
mutans at the concentrations 50, 100 and 150 μl was found to be 15 mm, 22 mm
and 20.6 mm respectively. Similarly for Lactobacillus, the zone of inhibition
was found to be 13 mm, 19 mm and 21.4 mm. For streptococcus aureus, the zones
of inhibition values were 17 mm, 21.2 mm and 21 mm respectively.
Please see the link :- https://www.ikprress.org/index.php/PCBMB/article/view/5301
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