The phytochemicals or secondary metabolites from extract of Citrus reticulata may cure dysentery, primarily which is caused by Entamoeba hystolytica. To restrict the activity of Entamoeba hystolytica, several bio molecules can be deployed, of which the phytochemicals can be the best alternative. Molecular docking-based screening of a few phytochemicals revealed that few of phytochemicals effectively associate with the active site of the Glyceraldehydes- 3 – Phosphate and hence bears diagnostic and therapeutic potentials against Entamoeba hystolytica causing dysentry. “High positive values of -CDOCKER energy and -CDOCKER interaction energy” indicated that the Anthranalic acid may effectively inhibit the glyceraldehydes-3-phosphate dehydrogenase enzyme thereby interrupting the life cycle of the organism.
Please see the link :- https://www.ikprress.org/index.php/PCBMB/article/view/5169
No comments:
Post a Comment